Accutane - Treatment of inflammation of the skin

Acne (Acne vulgaris), syn. teenage acne - a chronic, often relapsing disease characterized by purulent inflammation of the sebaceous glands.

Pathogenesis:
Acne is the result of imbalance of androgens in the body and, consequently, enhance sebaceous excretions. Ducts sebaceous glands clogged skin fat, and there are comedones - black eels. Standing in the blocked ducts sebum begins to decompose, forming a fertile breeding ground for pathogenic organisms, mainly coccal, corynebacteria, propionbaktery.
In the mechanism of development play a major role seborrhea, which reduces the bactericidal effect of sebum and leads to increased coccal flora.

Among the reasons for distinguished:
- Heredity
- Hormonal activity (menstruation, puberty)
- Stress that activates the adrenal glands
- Hyperactive sebaceous glands
- Accumulation of dead skin cells
- Microorganisms
- Skin damage accompanied by inflammation
- The use of anabolic steroids
- The application of preparations containing halogens (chlorine, bromine, iodine), lithium, and barbiturates
- Effects of high doses of chlorine (such as occupational hazards)

Hormone triggers acne are: testosterone, dihydrotestosterone, dehydroepiandrosterone, as well as insulin-like growth factor-1.

Treatment:

Exfoliation outer layers of skin

This manipulation can be accomplished through the use of abrasive material or liquid scrub, or chemically. Chemical exfoliating are ANA and VNA acid, removing the top layer of skin. They also cleanse the pores.

Topical microbicides:

Products containing benzoilperoksid used in the light forms of acne. Benzoilperoksid possesses keratolytic and antibacterial effects, killing P. acnes. Benhoilperoksid not cause resistance of bacteria. But often it is the use of drying of the skin, local irritation and redness.


Topical retinoids:



Tretinoin, adapalen, tazaroten are derivatives of vitamin A can significantly irritate the skin. Retinoids affect the life cycle of skin cells, thus normalize keratinization.

Retinoids used inside

Accutane normalises sebum production